Zbigniew Marczyński, Kazimiera Henryka Bodek, Marian Mikołaj Zgoda
Technologia otrzymywania tabletek niepowlekanych
zawierających suchy wyciąg z kwiatu bzu czarnego
Technology of the production of tablets containing a dry extract from Sambucus nigra flower. Four series of tablets containing a dry extract from Sambucus nigra flower were produced with the help of biodegradable and bioadhesive auxiliary substances and with pharmacopeal ethanol for granulate kneading. The obtained results allow to state that a spectrophotometric method, worked out and adapted for the determination of flavonoid compounds, may be useful in monitoring the process of active substances release from the extract in a tablet. The tablets which best comply with the pharmacopeal requirements are those produced from a dry extract from Sambucus nigra flower with the use of respectively: lactose and starch introduced in two portions as filling substances and microcrystalline cellulose (Avicel) and starch as filling substances, colloidal silica and Kollidon as bursting substances.