Marian Mikołaj Zgoda, Michał Jakub Nachajski
Rozpuszczalność lipofilowych środków leczniczych w wodnych roztworach alkoholi cukrowych
2007-07-22
Solubilization of lipophilic drug substances in aqueous solutions of sugar alcohols. Measured basic viscosity values of sugar alcohol aqueous solutions and of their hydrotrope adducts with selected drugs enabled calculation, in an equilibrium state, of solubilization indexes n/s for diclofenac, naproxen and ibuprofen. The pharmaceutical availability of NSAID from a model tablet in the environment of hypoosmotic solutions of glucose, mannitol, sorbitol and xylitol was measured by means of the pharmacopoeial method. The results obtained in the course of the present study serve as the basis for research into formulation of a quick-dissolving tablet with nonsteroidal anti-inflammatory drugs.