Formulacja przeciwzapalnych kropli do oczu z metylocelulozą
solubilizowanych micelarnymi roztworami polietero-n-oli
Formulation of anti-inflammatory eye drops with methylcellulose solubilized with micellar solutions of polyether-n-ols. Preparation of vehicles for eye drops and their application forms containing sodium diclofenac (DNa) and macromolecular adjuvant substances - methylcellulose (MH Tylose 300 and Methocel MC 400). The values of pH, osmolarity (?), viscosity (?) and surface tension (?) for all investigated compositions of vehicles for eye drops and their application forms containing DNa were determined. The critical micellar concentration (cmc) for adducts forming from the formulation components of the vehicle for eye drops was determined. Calculation of cmc has enabled for the calculation of micellar hydrophilic - lipophilic balance (HLBcmc) acc. to the method by Lin, Davies and Griffin, and of the thermodynamic potential of micelle formation (DG0m). The diffusion rate of ionic stream from eye drops with DNa through the dialyser to the external compartment (water) was measured. The measurements were done by conductometric method.