K. Wiglusz, L. Trynda-Lemiesz
Effect of fatty acids on the binding of drugs by human serum albumin
Ect of fatty acids on the binding of drugs by human serum albumin
Human serum albumin (HSA) is the most abundant protein constituent of blood plasma and has many important physiological functions.The bond of drugs to the blood proteins and especially to an albumin has a crucial signi cance for them therapeutic e ects only free part of drug could be active.Binding to HSA may a ect the distribution, metabolism and elimination of drug, as well as both pharmacokinetic and pharmacodynamic e ects of drug.In pathological states, running from hyperlipidemia, drugs binding to albumin may show, as amended by the pharmacokinetics and the therapeutic e ect after application of the standard regimen may not be satisfactory.Weak drug bound to albumin may increase the concentration of its free fraction in plasma and the severity of side e ects or acceleration of the eliminationOn the other hand a stronger binding of drug by albumin results in a reduction in drug concentration below the minimum therapeutic concentration (MEC) and the lack of pharmacological activity.
Keywords: fatty acids, human serum albumin, drug binding.