Barbara Malawska, Marta Kusak

Projektowanie leków wieloligandowych

Design of multiple ligands

In this article, new strategy for design of multi-functional drugs has been presented. Multiple ligands can reduce risk of poly-therapy and can improve patient compliance. Methodology of design of multiple ligands is based on a combination of structural fragments of two or more molecules, which interact with selective biological targets into a single molecule. Chemical modification of this new lead structure should improve activities at the different targets. The most common diseases areas for design of multiple ligands are hypertension, psychiatric disorders, metabolic disease or allergic disease, due to their multifactor pathomechanism. This methodology is presented on the two examples: ziprasidone (as the anti-schizophrenia agent) and omapatrilat (potential antihypertensive drug).
Keywords: drug design, multi-functional derivatives, design of multiple ligands, multiple targets approach, multi-functional drugs.