Mikołaj K. Głowacki, Tomasz Mach
Liver cirrhosis is a end-stage chronic liver disease, usually caused by viruses, alcohol, metabolic processes and also toxins, drugs or autoimmune diseases. In the paper a pathogenesis, etiology, and clinical symptoms of this serious disease were presented. The liver cirrhosis is characterized by fibrosis and occurrence of regenerative nodules, subsequently leading to portal hypertension, esophageal varices, impaired coagulation, ascites and oedems. The disease is usually diagnosed in late stages when many complications occur, including esophageal varices bleeding, spontaneous bacterial peritonitis, hepatorenal or hepatopulmonary syndrome, hepatic encephalopaty and heptocellular carcinoma. The only effective method of treatment is the liver transplantation. Important are stop of alcohol drinking, drug restrictions, antiviral therapies in chronic HBV or HCV infections and appropriate treatment of complications.
Keywords: liver cirrhosis, liver fibrosis, HBV, HCV, NAFLD.
© Farm Pol, 2011, 67(10): 698-704