Anna Jakubowska, Barbara Malawska
Poszukiwanie nowych leków w terapii choroby Alzheimera opartych na strukturze donepezilu
Search for new anti-Alzheimer’s drugs based on the structure of donepezil
Number of patients who suffer from Alzheimer’s disease is still increasing, and it is associated with an aging population of people in the world. However, the currently used drugs have only a supportive role and do not slow disease progression. Therefore, it is necessary to search for more effective, disease modifying agents, which also are able to slow down disease progression. Structural modifications of already existing drugs is a possible approach for searching new potential drugs. Design and synthesis of cholinesterases inhibitors based on the structure of donepezil, endowed beneficial properties is an example of such researches.
Keywords: Alzheimer disease, donepezil, cholinesterases inhibitors, β-amyloid
© Farm Pol, 2011, 67(11): 743-748