Katarzyna Klaś, Piotr Guzy, Kamil Piska, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz, Elżbieta Pękala

The application of in vitro models in a preclinical safety evaluation of new drug candidates
2018-02-02

DOI: 10.32383/farmpol/120045

The application of in vitro models in a preclinical safety evaluation of new drug candidates

In vitro models are an essential tool to determine the profile of activity and the safety of the drug candidate at the early stage of preclinical studies. Thanks to them it is possible to perform screening tests for thousands of active molecules in a short time and to predict their possible side effect. This allows to eliminate potentially dangerous compounds at a very early stage, before using animal models. This review presents the most important information about using in vitro methods, based on prokaryotic and eukaryotic cell models, in hepato-, neuro-, nephro-, cardio- and genotoxicity research of active compounds.

Keywords: alternative models, drug safety, drug development, drug toxicity.

c Farm Pol, 2018, 74(1): 45-51