Arkadiusz Gruchlik, Sławomir Smolik
Preparation of extemporaneous oral liquid medications in children’s hospital pharmacies
Oral liquid preparations are often used as the dosage form of choice in pediatric patients. Some of the drugs necessary for pediatric patients treatment are not commercially available in dosage forms appropriate for the use in this population. Pharmacists, both in community and hospital pharmacy practice, are often challenged with the extemporaneous preparation of oral liquids from commercially available products. There are no studies confirming the stability, bioavailability, pharmacokinetics, pharmacodynamics, efficacy and tolerability of such formulations. The shelf-life is assigned empirically or based on published information. Drugs as extemporaneously prepared liquids may be susceptible to chemical reactions leading to their degradation. The most common forms of the active substance of the drug are powdered tablets. The base of these formulations in Polish conditions is generally water or simple syrup.
Keywords: extemporaneous dosage form, pediatric preparation, extemporaneous preparations
© Farm Pol, 2018, 74 (4): 260–264