Making extemporaneous suspensions from solid oral dosage forms as the way of age-appropriate personalized pharmacotherapy
Difficulties of the oral solid dosage form intake are particularly often among paediatric population and geriatric patients, who suffer from dysphagia. Also, the unadjusted dose can make the drug dispense impossible. For those patients, there is a possibility to prepare personalized liquid dosage form in the hospital pharmacy. There, the suspension can be made using oral solid form – tablets or capsules – which are available on the market. The suspension base can be made of common easily available ingredients such as simple syrup or cellulose derivatives’ gels. The type of the additions used significantly change the suspension properties and affect its physical, chemical and microbiological stability as well as impact on the suspended drug bioavailability. This article presents examples of the suspensions’ recipes, containing furosemide, spironolactone and omeprazole prepared from oral dosage forms and pharmaceutical ingredients available on the market.
Keywords: suspension, bioavailability, oral solid dosage form, dysphagia, paediatric population
© Farm Pol, 2018, 74 (4): 254–259