Julia Lewandowska, Jan Maciej Kapała, Łukasz Puchała

Therapeutic Potential of Dronabinol: A Systematic Review of Human Trials
2021-09-30

Therapeutic Potential of Dronabinol: A Systematic Review of Human Trials

Dronabinol is an isomer of tetrahydrocannabinol that seems to have the potential for both somatic and psychiatric disorders treatment. The purpose of this review is to provide an overview of collected articles with emphasis on the efficacy and safety of dronabinol pharmacotherapy. A literature review was performed in May 2021. Three databases (PubMed, ClinicalTrials, and Cochrane Library) were searched using the following terms: “Dronabinol”, “Marinol”, “Syndros” and “Namisol” for published studies in English in 2016–2021. Finally, 29 articles were included: 27 randomized controlled clinical trials (RCTs), one open-label clinical trial, and one combination of both previously mentioned designs. According to reviewed studies, dronabinol could be a therapeutic option for cannabis use disorder, Obstructive Sleep Apnea (OSA), Tourette Syndrome (TS), relieving stress, and anorexia treatment.

Keywords: Dronabinol, Systematic review, Clinical trials, Clinical pharmacy.

© Farm Pol, 2021, 77(8): 477–490