Rafał Mastalerz, Natalia Kocot, Jacek Dulęba, Tomasz Siódmiak, Michał Piotr Marszałł

The therapeutic potential of rosehip in osteoarthritis
2022-04-15

Osteoarthritis is characterized by changes in metabolism, structure, and functioning of joints as well as surrounding tissues. Pathomechanism of this disease is associated with increased secretion of inflammatory mediators. An important role in the pathogenesis of osteoarthritis is also played by the activation of NF-κB signaling pathway, which is a protein complex that can induce transcription of the catabolic enzyme genes and stimulate the secretion of inflammatory mediators.

Pharmacotherapy of osteoarthritis is based mainly on the reduction of inflammation. One of the sources of active substances with anti-inflammatory activity is the rosehip of Rosa canina L. (Rosaceae). This raw material contains, among others, GOPO (galactolipid), polyunsaturated fatty acids ω-3 and ω-6 PUFAs: