Abdel-Hameed Ibrahim Mohamed, Samia Ali Abdo Gamie, Donia Mohamed Eid, Sara Mohamed Mohamed

Safety and Efficacy of Hybrid, Triple and Quadruple Regimens for Management of Helicobacter Pylori Infection in Egyptian Patients

2025-01-14

Helicobacter pylori (H.pylori) poses a major risk to human health, and managing of this pathogen is very challenging due to increased antibiotic resistance. Additionally, the lack of data about optimunm regimens use for H. pylori management makes treatment even more challenging.

Objective. To determine whether the hybrid regimen is safe and effective as a first-line treatment for H.pylori.

Methods. A prospective research enrolled Egyptians with H. pylori infection. Patients were randomly assigned to one of three groups: group one received a triple regimen consisting of PPI, amoxicillin, and clarithromycin, group two received a quadruple regimen consisting of PPI, amoxicillin, clarithromycin, and metronidazole, and group three received a hybrid regimen consisting of PPI, amoxicillin for 7 days followed by clarithromycin and metronidazole addition for another 7 days.

Main outcomes measures. The efficacy of the three regimens was assessed by analyzing stool antigen test (SAT) results after treatment cessation, while safety was evaluated based on reported side effects.

Results. Eighty percent of patients in the hybrid regimen group had negative re-test results, compared to 65% in the quadruple regimen group and 35% in the triple regimen group. Additionally, the hybrid regimen showed the least incidence of side effects.

Conclusion. The hybrid regimen offers the highest efficacy and safety for H.pylori eradication in Egyptian patients.

Keywords: Helicobacter Pylori, Hybrid regimen, Quadruple regimen, Triple regimen, Antibiotic resistance, Stool antigen test.

© Farm Pol, 2024, 80(8): 535–545