Tomasz Zawiła, Denis Swolana, Robert Wojtyczka

Aktywność przeciwgronkowcowa kwasu cynamonowego i jego pochodnych

 

2026-04-09

Antistaphylococcal activity of cinnamic acid and its derivatives

Cinnamic acid derivatives, such as ferulic, p-coumaric, and sinapic acids, are naturally occurring phenolic compounds with biological potential attributed to their anti-oxidant and anti-inflammatory activities. They neutralize free radicals and modulate oxidative stress pathways, which may be relevant in the prevention of degenerative diseases. Studies also report antimicrobial effects; however, minimal inhibitory concentrations (MICs) are generally high, limiting the applicability of these compounds as monotherapies. Promising results have been observed in combination therapies with antibiotics, where synergistic effects enhance microbial susceptibility, including in resistant strains. Variability in experimental outcomes arises from differences in extraction methods and preparation characteristics, underscoring the need for further mechanistic investigations and in vivo studies.

Keywords: cinnamic acid derivatives, phenolic compounds, antimicrobial activity, antioxidants, antibiotic synergism, phytochemistry.

© Farm Pol, 2025, 81(8): 501–508